The impact of hyperoxia on the neonatal and adult developing dendritic cell

Oxygen is essential therapy for neonates with acute respiratory failure, including those with infections. However, high oxygen levels may be counterproductive for overcoming infections because hyperoxia may kill cells, including dendritic cells that are essential to the emergence of the pulmonary immune system and pivotal in mounting immune responses to infections. We studied the impact of hyperoxia on developing dendritic cells from neonatal cord blood and adult blood monocytes, comparing viability, development of maturation, and endocytic function. Our data suggest that cord blood-derived dendritic cells may be more resistant to hyperoxic-induced cell death than adult blood-derived cells. Moreover, the surviving cells in either group are those that maintain an immature phenotype. This may impair their ability to perform optimal immune function.