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Related Experiment Video

Updated: Jul 14, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Cyclooxygenase 2 expression in pterygium.

Chun-Chi Chiang¹, Ya-Wen Cheng, Chien-Lin Lin

¹Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan. elsa10019@yahoo.com.tw <elsa10019@yahoo.com.tw>

Molecular Vision

|May 23, 2007

Summary

Cyclooxygenase 2 (COX 2) was found in pterygium tissue, suggesting it may play a role in pterygium formation. This finding could lead to new COX 2 inhibitor treatments for pterygium.

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Last Updated: Jul 14, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

Ophthalmology
Oncology
Molecular Biology

Background:

Pterygium, a conjunctival overgrowth, is increasingly viewed as a neoplastic condition due to abnormal p53 gene expression.
Ultraviolet (UV) radiation is a known risk factor for pterygium, but the underlying cellular mechanisms remain unclear.
Cyclooxygenase 2 (COX 2) is implicated in UV-induced skin cancer, prompting investigation into its role in pterygium.

Purpose of the Study:

To investigate the expression of cyclooxygenase 2 (COX 2) in pterygium tissues.
To determine if COX 2 is present in pterygium and its cellular localization.

Main Methods:

Immunohistochemical staining was employed to detect COX 2 expression.
The study analyzed 90 pterygium specimens, alongside 40 normal conjunctiva and 5 normal limbus samples.

Main Results:

COX 2 expression was detected in 83.3% of pterygium specimens.
Staining was primarily localized to the cytoplasm of the epithelial layer, particularly the basal layer.
No significant COX 2 staining was observed in normal conjunctiva or limbus tissues.

Conclusions:

The presence of COX 2 in pterygium suggests its potential involvement in pterygium development.
These findings support the hypothesis that pterygium shares carcinogenic pathways with UV-induced cutaneous tumors.
Further research into the causal link between COX 2 and pterygium, and the efficacy of COX 2 inhibitors, is warranted.