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Updated: Jul 14, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Current role of LC-MS in therapeutic drug monitoring
Franck Saint-Marcoux1, François-Ludovic Sauvage, Pierre Marquet
1Department of Pharmacology-Toxicology, Limoges University Hospital, Unité INSERM U850, 87042 Limoges cedex, France.
Abstract:
The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics. For each class of compounds, we focussed on the most interesting methods and evaluated the current role of LC-MS in therapeutic drug monitoring.
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