Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model neural interface based on functional chemical stimulation.

Neville Z Mehenti1, Harvey A Fishman, Stacey F Bent

  • 1Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

Biomedical Microdevices
|May 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SEI Characterization Using XPS: Resolving Rinsing Effects through Cryogenic Implementation.

ACS applied materials & interfaces·2026
Same author

Atomic layer-deposited nucleation layers to control zinc morphology and suppress hydrogen evolution.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Anhydrous Atomic Layer Deposition of HfO<sub>2</sub>: Mechanistic Analysis of the Tetrakis(dimethylamido)hafnium (TDMAH)-O<sub>2</sub> Process.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Cryogenic X-ray photoelectron spectroscopy for battery interfaces.

Nature·2025
Same author

Effect of Networking Density on the Patterning Performance of Molecular Layer Deposited Alucone Electron Beam/EUV Resists.

ACS applied materials & interfaces·2025
Same author

Precursor Engineering of Atomic Layer Deposition for Top-Gate Insulators on Monolayer MoS<sub>2</sub> Transistors.

ACS nano·2025
Same journal

A pump-free gravity-driven microfluidic chip for rapid RPA-LFS-based detection of Magnaporthe oryzae AvrPi9 gene.

Biomedical microdevices·2026
Same journal

Mechanotherapeutic biomaterials: Overcoming physical barriers to enhance intratumoral drug delivery in solid tumours.

Biomedical microdevices·2026
Same journal

Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures.

Biomedical microdevices·2026
Same journal

3D printed chip as platform to vascularize hiPSCs-derived kidney organoids.

Biomedical microdevices·2026
Same journal

Ingestible smart capsules: from engineering innovation to GI drug delivery.

Biomedical microdevices·2026
Same journal

An inexpensive, portable, refrigeration-free, ready-to-use microfluidic device for real-time multiplexed molecular detection of HIV, HBV, and HCV.

Biomedical microdevices·2026
See all related articles

This study introduces a new neurotransmitter-based prosthetic interface that uses chemical pulses to stimulate neurons, offering a biomimetic solution for neurological disorders where electrical stimulation falls short.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Functional electrical stimulation (FES) is limited in treating neurological disorders as it cannot replicate neurochemical functions.
  • Existing prosthetic interfaces often fail to address pathways primarily governed by neurochemical signaling.

Purpose of the Study:

  • To develop and characterize a novel neurotransmitter-based prosthetic interface for selective chemical stimulation of neurons.
  • To demonstrate the potential of this interface in restoring physiological functions beyond the scope of electrical stimulation.

Main Methods:

  • A flexible microdevice with a polymer membrane aperture was designed for selective chemical pulse release.
  • Microfluidic switching controlled release profiles, characterized using fluorescence microscopy.

Related Experiment Videos

  • Hippocampal neurons cultured on the microdevices were stimulated with glutamate, and responses were monitored via calcium imaging.

    • Main Results:

    • The microdevice successfully delivered controlled chemical pulses, with release profiles tunable by pulse duration and frequency.
    • Glutamate delivery via the microdevice elicited discrete action potentials in cultured hippocampal neurons.
    • Single-cell stimulation at 2 Hz was achieved, demonstrating precise control over neural activation.

    Conclusions:

    • The developed neurotransmitter-based prosthetic interface offers a biomimetic platform for functional chemical stimulation.
    • This technology may restore physiological pathways and functions that cannot be addressed by electrical stimulation alone.
    • Further development could lead to advanced neuroprosthetics for treating a wider range of neurological disorders.