The effect of aluminium phosphide on the human brain: a histological study

The study was conducted on 317 cases of poisoning in the Varanasi region, India, between January 2002 and August 2003. Aluminium phosphide (Celphos) was used by 239 victims (75.40% of the total) and was used in 69.03% of male and 30.96% of female cases. It was commoner in males from both rural and urban areas and in the 21-30 year age group. Microscopic investigation of the cerebral and cerebellar cortex showed distinct changes due to the effect of celphos. Findings in the cerebral cortex revealed disorganisation of the different layers, round shaped neurons with a convex border, degenerated Nissl granules in the cytoplasm and a deeply stained degenerated eccentric nucleus. Findings in the cerebellar cortex included degenerated neurons, the infiltration of round cells into the molecular layer and the disappearance of the processes of Purkinje cells. Degenerate nuclei were surrounded by scavenger cells in the granular layer. The subcortical zone of the brain revealed a paucity of glial cells, degeneration of nerve fibres and the appearance of necrotic patches.