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Iodine-mediated synthesis of indolyl-1,3,4-thiadiazole amine derivatives and their DFT analysis
Vartika Vaishya1, Manish K Mehra2, S K Pandey3
1Department of Chemistry, School of Physical and Biological Sciences, Manipal University Jaipur, VPO- Dehmi-Kalan Off Jaipur-Ajmer Express Way Jaipur Rajasthan 303007 India meenakshi.pilania@jaipur.manipal.edu meenakshi.pilania1987@gmail.com.
Abstract:
An effective iodine-mediated one-pot three-component strategy for the construction of indolyl-1,3,4-thiadiazole amines has been described. The method involved the reaction of tosylhydrazine with indole-3-carboxaldehyde and ammonium thiocyanate as a non-toxic source of sulphur under metal-free conditions. The developed protocol included readily available substrates, shorter reaction time, use of low-toxic thiocyanate, and benzylation with a broad substrate scope, making it a viable approach for multiple applications. Furthermore, DFT analysis was conducted using the Gaussian 09 package.
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