Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relapse versus reinfection with Clostridium difficile.

G L O'Neill1, M H Beaman, T V Riley

  • 1Department of Microbiology, University of Western Australia, Nedlands.

Epidemiology and Infection
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clostridioides difficile colonization and infection in a cohort of Australian adults with cystic fibrosis.

The Journal of hospital infection·2021
Same author

Clostridium difficile and One Health.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

In silico, in vitro and in vivo analysis of putative virulence factors identified in large clostridial toxin-negative, binary toxin- producing C. difficile strains.

Anaerobe·2019
Same author

Recurrence of Clostridium difficile infection in the Western Australian population.

Epidemiology and infection·2019
Same author

Status of vaccine research and development for Clostridium difficile.

Vaccine·2019
Same author

Natural products show diverse mechanisms of action against Clostridium difficile.

Journal of applied microbiology·2018
Same journal

Epidemiological Investigation of a Large Trichinellosis Outbreak in Lebanon, October 2023 - February 2024.

Epidemiology and infection·2026
Same journal

Pandemic preparedness: potential of routine general practice data for infectious disease early signal detection.

Epidemiology and infection·2026
Same journal

ASSOCIATION BETWEEN INTRODUCTION OF 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE AND BURDEN OF HOSPITALIZED ADULT PNEUMOCOCCAL DISEASE IN TAIWAN - A RETROSPECTIVE DATABASE STUDY.

Epidemiology and infection·2026
Same journal

Using forensic autopsy data to estimate the age-specific infection fatality risk of COVID-19.

Epidemiology and infection·2026
Same journal

Maternal and congenital syphilis in Fiji 2019-2022: a secondary analysis of clinical trial data.

Epidemiology and infection·2026
Same journal

The Socio-economic Shield Limits Lassa Virus Spillover in Urban West Africa.

Epidemiology and infection·2026
See all related articles

Clostridium difficile-associated diarrhea relapses are often caused by new infections, not the same bacteria returning. Multiple strain carriage in the gut appears to be rare, suggesting reinfection is a common cause of recurrent C. diff.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Clostridium difficile-associated diarrhea (CDAD) frequently relapses in 15-20% of patients.
  • The source of recurrent CDAD, whether endogenous or exogenous reinfection, remains incompletely understood.

Observation:

  • Restriction enzyme analysis (REA) was used to investigate the source of CDAD relapse in ten patients.
  • Multiple C. difficile strains were assessed for carriage in ten additional patients.

Findings:

  • Over half of observed CDAD relapses were attributed to infection with a new C. difficile strain.
  • In patients relapsing with the same strain, the source (endogenous vs. environmental) was indeterminate.
  • Analysis indicated that carriage of multiple C. difficile strains within the gastrointestinal tract is likely a rare event.

Related Experiment Videos

Implications:

  • Understanding the source of CDAD relapse is crucial for developing effective treatment and prevention strategies.
  • Findings suggest that environmental reinfection with new strains plays a significant role in CDAD recurrence.
  • The rarity of multiple strain carriage implies that interventions targeting a single strain may be sufficient for some patients.