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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Subacute sclerosing panencephalitis in Croatia (1994-2004)
Tatjana Vilibic Cavlek1, Suncanica Ljubin Sternak, Bernard Kaic
1Croatian National Institute of Public Health, Zagreb. tatjana.vilibic-cavlek@hzjz.hr
Acta Microbiologica Et Immunologica Hungarica
|May 26, 2007
Summary
Subacute sclerosing panencephalitis (SSPE) was studied in five vaccinated patients. Measles virus (MV) wild-type D6 genotype was identified in brain tissue, indicating potential SSPE development despite vaccination.
Area of Science:
- Neurology
- Virology
- Immunology
Background:
- Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disorder.
- While measles vaccination is highly effective, rare cases of SSPE can still occur.
- Understanding the role of measles virus (MV) in vaccinated individuals is crucial.
Purpose of the Study:
- To investigate the clinical and virological characteristics of SSPE in vaccinated patients.
- To identify the measles virus genotype responsible for SSPE in these cases.
Main Methods:
- Analysis of five SSPE patients over a 10-year period.
- Serological testing (complement-fixation test, EIA) for measles virus antibodies in CSF and serum.
- Detection of MV antigen (IFA), viral RNA (RT-PCR), and viral inclusions (electron microscopy) in brain tissue.
Main Results:
- All patients exhibited high measles virus antibody titers in serum and CSF.
- Measles virus antigen and RNA were detected in brain tissue.
- Nucleotide sequence analysis confirmed the presence of wild-type measles virus D6 genotype.
Conclusions:
- SSPE can develop in individuals vaccinated against measles.
- Wild-type measles virus D6 genotype is implicated in SSPE pathogenesis.
- Further research is needed to understand SSPE mechanisms in vaccinated populations.
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