Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peroxisomes

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

Peroxisomes

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

Radical Autoxidation

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...

Bioactivation and Tissue Toxicity

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic Responses of Melanocytes and Melanoma Cells to UVA Radiation and Phytocannabinoids Exposure.

Antioxidants (Basel, Switzerland)·2026

Same author

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Assessing the Malignant Potential of Gastric Mucosa Disorders: A Pilot Study on Lipid Peroxidation End Products and COX-2 Detection by Immunohistochemistry.

Molecular carcinogenesis·2026

Same author

Modulation of Redox Balance by Phytochemicals: Implications for Cardiovascular Health.

Nutrients·2026

Same author

Cannabigerol Reduces Lipid Peroxidation Influencing Oxidative Stress and Inflammation Signaling Pathways in Melanocytes Exposed to UVA Radiation.

Frontiers in bioscience (Landmark edition)·2026

Same author

Integrative Analysis of 4-Hydroxynonenal-Modified Proteins and Plasma Metabolome in Breast Cancer Patients.

Antioxidants (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Non-Enzymatic Lipid Peroxidation in Cancer Biology: An Overview.

Morana Jaganjac¹, Anita Stojanović Marković¹, Mirna Halasz¹

¹Laboratory for Oxidative Stress, Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.

Frontiers in Bioscience (Landmark Edition)

|July 7, 2026

Summary

Oxidative stress in cancer disrupts redox balance, leading to lipid peroxidation (LPO). This process has a dual role, promoting and suppressing tumors, offering potential for new anticancer treatments.

Keywords:

4-hydroxynonenal (HNE)apoptosis carcinogenesis ferroptosis lipid peroxidation oxidative stress reactive oxygen species (ROS)tumor lipidome

More Related Videos

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

Published on: November 21, 2011

Related Experiment Videos

Last Updated: Jul 8, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

Published on: November 21, 2011

Area of Science:

Biochemistry
Oncology
Cell Biology

Background:

Cancer involves disrupted redox balance and impaired antioxidant defenses, causing oxidative stress.
Oxidative stress induces lipid peroxidation (LPO), generating reactive aldehydes like 4-hydroxynonenal (HNE).
HNE acts as a reactive oxygen species (ROS) messenger, influencing cell behavior and potentially cancer development.

Purpose of the Study:

To provide a comprehensive overview of non-enzymatic LPO in cancer.
To highlight the dual role of LPO in tumor promotion and suppression.
To discuss how LPO dynamics and ferroptosis susceptibility are shaped by the tumor microenvironment and metabolic changes.

Main Methods:

Literature review of non-enzymatic lipid peroxidation in cancer.
Analysis of the role of oxidative stress, metabolic reprogramming, and lipidome remodeling.
Exploration of emerging therapeutic strategies targeting LPO.

Main Results:

Persistent oxidative stress and metabolic reprogramming influence LPO dynamics.
The tumor microenvironment and lipidome remodeling affect ferroptosis susceptibility.
LPO exhibits a dualistic nature, acting as both a cofactor in carcinogenesis and a natural defense against cancer.

Conclusions:

Understanding the dual role of LPO is crucial for cancer research.
Exploiting LPO's dual nature may lead to individualized and effective anticancer therapies.
Integrative biomedicine approaches can leverage LPO for novel cancer treatments.