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HIV-infected children vaccination coverage and safety in a Western European cohort: a retrospective study

María Fernández-Ibieta1, José T Ramos-Amador, Ismael Auñón-Martín

  • 1Immunodeficiency Unit, Paediatric Department, Hospital 12 de Octubre, Ctra. Andalucia s/n Madrid 28014, Spain. mfndezibieta@hotmail.com

International Journal of STD & AIDS
|May 26, 2007
PubMed

Insights

Vaccine coverage in children with HIV is suboptimal, particularly for vaccines administered in primary care. Oral polio vaccine was safe, but overall immunization rates require improvement to prevent future illness.

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Highly active antiretroviral therapy has improved outcomes for children with HIV.
  • Vaccine response in HIV-infected children is crucial for preventing morbidity and mortality.
  • Assessing current vaccination status in this population is essential.

Purpose of the Study:

  • To determine vaccine coverage in HIV-infected children and adolescents.
  • To evaluate vaccine safety and adherence to recommendations.
  • To compare vaccine uptake between primary care and hospital settings.

Main Methods:

  • Retrospective review of medical records for 68 HIV-infected children and adolescents.
  • Analysis of coverage for specific vaccines including oral polio vaccine (OPV), hepatitis B virus (HBV), varicella, pneumococcal, meningococcal, and influenza vaccines.
  • Assessment of vaccine safety and concordance with recommendations.

Main Results:

  • Suboptimal vaccine coverage was observed overall.
  • Oral polio vaccine (OPV) coverage was 44%; only 9.1% received a second HBV series due to low response.
  • Varicella vaccination was low (14.7%), while pneumococcal (23-valent: 82.3%, 7-valent: 100%) and meningococcal (80.8%) coverages were higher. Influenza vaccination was poor (22.7%).
  • Vaccine uptake was lower for immunizations administered in primary care compared to hospitals.
  • OPV administration was safe with no adverse effects.

Conclusions:

  • Vaccine coverage in HIV-infected children is suboptimal.
  • Immunization rates are lower for vaccines given in primary care settings.
  • Targeted interventions are needed to improve vaccination rates in this vulnerable population.

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