Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutation-selection balance and metabolic control theory.

A G Clark1

  • 1Department of Biology, Pennsylvania State University, University Park 16802.

Genetics
|November 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlated Gene Copy Number Changes in a Seminal Fluid Protein Network in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2025
Same author

The influence of open-top chambers on the growth and development of field bean.

The New phytologist·2021
Same author

Sex-ratio meiotic drive and interspecific competition.

Journal of evolutionary biology·2014
Same author

Using next-generation RNA sequencing to identify imprinted genes.

Heredity·2014
Same author

Non-conflict theories for the evolution of genomic imprinting.

Heredity·2014
Same author

Evidence for horizontal and vertical transmission in Campylobacter passage from hen to her progeny.

Journal of food protection·2012
Same journal

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

Genetics·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
Same journal

Identification of two Cryptococcus neoformans heme transporters involved in Fhb1-mediated nitrosative stress protection in a fission yeast model.

Genetics·2026
Same journal

Analysis of a hypomorphic mei-P26 mutation reveals coordination between developmental programming of germ cells and meiotic chromosome dynamics.

Genetics·2026
See all related articles

This study models the evolution of metabolic control, showing how enzyme activity variations can lead to skewed distributions. It suggests mutation-selection balance may explain enzyme activity variance in metabolic pathways.

Area of Science:

  • Evolutionary Biology
  • Systems Biology
  • Quantitative Genetics

Background:

  • Metabolic control theory and quantitative genetics offer insights into metabolic pathway regulation.
  • Enzyme activities (Vmax/Km) are key quantitative traits influenced by polygenic mutation.
  • Stabilizing selection acts on global pathway properties like flux or metabolite concentrations.

Purpose of the Study:

  • To unify classical quantitative genetics and metabolic control theory in models of metabolic control evolution.
  • To investigate how polygenic mutation and stabilizing selection shape enzyme activities within metabolic pathways.
  • To analyze equilibrium distributions and correlations of enzyme activities under evolutionary pressures.

Main Methods:

  • Developed models integrating quantitative genetics and metabolic control theory.

Related Experiment Videos

  • Simulated polygenic mutation altering enzyme activities.
  • Applied haploid viability selection and stabilizing selection on pathway flux or metabolite concentrations.
  • Utilized analytical results and numerical simulations, including the house-of-cards approximation.

    • Main Results:

    • Demonstrated skewed, non-Gaussian equilibrium distributions for enzyme activities.
    • Observed a positive correlation between activities of enzymes flanking a selected substrate pool.
    • Validated the house-of-cards approximation for predicting allelic effect distributions.

    Conclusions:

    • The models provide a framework for understanding the evolution of metabolic control.
    • Mutation-selection balance is a potential explanation for observed enzyme activity variance.
    • Further research is needed to confirm this hypothesis, with the system offering a suitable testbed.