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Related Experiment Videos

BDNF induction with mild exercise in the rat hippocampus.

Hideaki Soya1, Toru Nakamura, Custer C Deocaris

  • 1Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, 1-1-1 Tennoudai, Tsukuba 305-8574, Japan. hsoya@taiiku.tsukuba.ac.jp

Biochemical and Biophysical Research Communications
|May 26, 2007
PubMed
Summary
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Mild, low-intensity exercise, unlike strenuous activity, can activate the hippocampus and boost brain-derived neurotrophic factor (BDNF) expression. This suggests less stressful physical activity may offer greater benefits for brain function.

Area of Science:

  • Neuroscience
  • Exercise Physiology

Background:

  • Chronic voluntary exercise enhances hippocampal brain-derived neurotrophic factor (BDNF).
  • The impact of acute, forced exercise on hippocampal BDNF remains under-investigated.

Purpose of the Study:

  • To investigate the effects of acute exercise intensity on neuronal activation (c-fos) and BDNF expression in the hippocampus.
  • To determine if exercise intensity influences BDNF mRNA and protein levels.

Main Methods:

  • Mice were subjected to acute treadmill exercise at varying intensities (low: 15 m/min, moderate: 25 m/min).
  • Expression levels of c-fos mRNA and BDNF mRNA and protein were measured.
  • Blood lactate and corticosterone levels were monitored.

Main Results:

Related Experiment Videos

  • c-fos mRNA (neuronal activation marker) increased with low-intensity running and was intensity-dependent.
  • BDNF mRNA and protein levels were elevated only at low-intensity running.
  • Moderate-intensity running depressed BDNF mRNA and protein induction, despite increased blood lactate and corticosterone.

Conclusions:

  • Acute, low-intensity exercise minimally stresses the hippocampus, promoting neuronal activation and BDNF expression.
  • Mild exercise may confer greater benefits for hippocampal function compared to strenuous exercise.
  • Exercise intensity is a critical factor in modulating hippocampal BDNF responses.