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Updated: Jul 14, 2026
09:44
High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
Published on: March 3, 2015
Modulation of TSHR signaling by posttranslational modifications
1Medical Department III, University of Leipzig, Ph.-Rosenthal-Str. 27, 04103 Leipzig, Germany.
Trends in Endocrinology and Metabolism: TEM
|May 26, 2007
Summary
Posttranslational modifications significantly impact seven transmembrane receptors (7TMRs) function. New research highlights sialylation and dimerization of the thyrotropin-stimulating hormone receptor (TSHR), influencing its cell-surface expression and signaling pathways.
Area of Science:
- Biochemistry
- Molecular Biology
- Endocrinology
Background:
- Seven transmembrane receptors (7TMRs) undergo posttranslational modifications (PTMs) like glycosylation and phosphorylation, affecting their function.
- Recent studies reveal novel PTMs for the thyrotropin-stimulating hormone receptor (TSHR), including sialylation and dimerization.
Purpose of the Study:
- To explore the functional consequences of emerging posttranslational modifications on the thyrotropin-stimulating hormone receptor (TSHR).
- To discuss the implications of TSHR sialylation, dimerization, and novel signaling pathways.
Main Methods:
- Characterization of novel posttranslational modifications of the TSHR.
- Analysis of TSHR cell-surface expression and signaling pathways.
Main Results:
- Increased sialylation of TSHR leads to enhanced cell-surface expression.
- TSHR oligomerization and potential signaling modifications within lipid rafts warrant further investigation.
- TSHR signaling involves G-protein-coupled receptor kinases (GRKs) and arrestins, impacting the mitogen-activated protein kinase (MAPK) pathway.
Conclusions:
- Emerging posttranslational modifications significantly influence TSHR function and signaling.
- Further research is needed to fully elucidate the role of TSHR oligomerization and lipid raft interactions in its signaling cascade.
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