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Related Experiment Video

Updated: Jul 14, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Changing treatment protocol from azathioprine to mycophenolate mofetil: decrease in renal dysfunction, increase in

V Pourfarziani¹, Y Panahi, S Assari

¹Nephrology/Urology Research Center (NURC), Kidney Transplant Department, Baqiyatallah Medical Sciences University, Tehran, Iran. vahid.pourfarziani@gmail.com

Transplantation Proceedings

|May 26, 2007

Summary

The shift from azathioprine (AZA) to mycophenolate mofetil (MMF) improved kidney transplant survival but increased infection-related hospitalizations. Careful monitoring is crucial for patients on MMF to manage these risks.

Related Experiment Videos

Last Updated: Jul 14, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Area of Science:

Nephrology
Immunosuppression
Transplantation Medicine

Background:

Renal transplantation immunosuppression protocols have evolved from azathioprine (AZA) to mycophenolate mofetil (MMF).
This transition aimed to improve patient and graft outcomes post-kidney transplant.
Understanding the impact on rehospitalization causes is critical for optimizing care.

Purpose of the Study:

To compare the impact of azathioprine (AZA) versus mycophenolate mofetil (MMF) immunosuppression on rehospitalization causes.
To evaluate differences in patient and graft survival between AZA and MMF cohorts.
To analyze post-transplant admission data, including reasons, timing, and critical care needs.

Main Methods:

Retrospective cohort study of 893 kidney transplant recipients.
Comparison of 289 patients on AZA (1998-1999) versus 567 patients on MMF (2000-2001).
Analysis of long-term survival, rehospitalization rates, causes, ICU admissions, and mortality.

Main Results:

Five-year patient survival improved from 85% (AZA) to 91% (MMF) (P=.013).
MMF cohort showed significantly fewer rejections (35% vs 62%) but more infections (50% vs 37%) compared to AZA.
Marginally increased mortality (5% vs 2%) and ICU admission (6% vs 3%) observed in the MMF group.

Conclusions:

Mycophenolate mofetil (MMF) offers improved graft survival over azathioprine (AZA) in kidney transplantation.
The shift to MMF is associated with a significant increase in infection-related rehospitalizations.
While beneficial, MMF necessitates vigilant management to mitigate risks of infectious complications.