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SERUM LEVELS OF FIBROBLAST GROWTH FACTOR 21 IN TYPE 2 DIABETIC PATIENTS.

Y Panahi¹, S Bonakdaran², M A Yaghoubi²

¹Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Acta Endocrinologica (Bucharest, Romania : 2005)

|June 1, 2019

Summary

Elevated serum FGF21 levels are associated with poor type 2 diabetes control in an Iranian population. Further research is needed to understand the prognostic role of Fibroblast Growth Factor 21 (FGF21) in diabetes.

Keywords:

Fibroblast growth factor 21 Glycemic control Insulin resistance Type 2 diabetes

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Area of Science:

Endocrinology
Metabolic Research
Clinical Biochemistry

Background:

Fibroblast growth factor 21 (FGF21) is recognized as a metabolic regulator.
The precise physiological functions of FGF21 remain under investigation.
Understanding FGF21's role in diabetes is crucial for metabolic health.

Purpose of the Study:

To investigate serum FGF21 levels in individuals with type 2 diabetes in Iran.
To assess the correlation between FGF21 levels and diabetes control.
To compare FGF21 levels in diabetic and non-diabetic populations.

Main Methods:

Cross-sectional study involving 141 participants with type 2 diabetes and 26 healthy controls.
Measurement of fasting serum glucose, HbA1c, lipids, urea, and creatinine.
Quantification of serum FGF21 concentrations using ELISA, categorizing diabetic patients by HbA1c levels.

Main Results:

Mean serum FGF21 was significantly higher in the diabetic group (337.89±283.67 ng/L) compared to controls (237.25±43.22 ng/mL).
Poorly controlled diabetics exhibited significantly higher FGF21 levels than well-controlled diabetics and healthy controls (p=0.02).
No significant association was found between FGF21 levels and BMI, lipid profiles, or diabetic complications.

Conclusions:

Elevated serum FGF21 levels are linked to poor glycemic control in type 2 diabetes.
Further studies are recommended to explore the prognostic significance of elevated FGF21 in diabetic patients.
FGF21 may serve as a potential biomarker for diabetes management.