Related Experiment Videos
Polyene antibiotics in the membrane environment
Z Shervani1, A K Sarkar, B K Bachhawat
1Department of Biochemistry, University of Delhi, India.
Indian Journal of Biochemistry & Biophysics
|August 1, 1991
Abstract:
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.