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Actinomadura madurae causing mycetomas in Madras
1Institute of Microbiology and Pathology, Madras Medical College.
Indian Journal of Pathology & Microbiology
|April 1, 1991
Summary
Actinomadura madurae caused mycetoma in 73 cases studied in India. Cream-colored granules were characteristic, and lesions responded well to Streptomycin and dapsone treatment.
Area of Science:
- Medical Mycology
- Pathology
- Infectious Diseases
Background:
- Mycetoma is a chronic, granulomatous infectious disease.
- It is caused by fungi or aerobic actinomycetes.
- Actinomadura species are a common cause of mycetoma.
Purpose of the Study:
- To investigate the histopathological features of mycetoma cases.
- To identify the causative agents of mycetoma in Tamil Nadu, India.
- To evaluate treatment response in mycetoma patients.
Main Methods:
- Histopathological examination of 210 mycetoma cases diagnosed between 1964-1987.
- Isolation of causative organisms in pure culture from clinical samples.
- Clinical data review for treatment response.
Main Results:
- Actinomadura madurae was identified in 73 out of 210 cases (34.8%).
- A. madurae was isolated in pure culture from nine cases of mycetoma pedis.
- Characteristic cream-colored granules were observed in all cases.
- Lesions showed good response to a combination of Streptomycin and dapsone.
Conclusions:
- Actinomadura madurae is a significant causative agent of mycetoma in the studied region.
- Histopathology and culture are crucial for diagnosing mycetoma.
- Combination therapy with Streptomycin and dapsone appears effective for treating A. madurae mycetoma.