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Updated: Sep 28, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
Tympanic membrane breakdown after intratympanic injection of steroids in irradiated ears
Yisgav Shapira1, Fred F Telischi
1University of Miami School of Medicine, Department of Otolaryngology, University of Miami Ear Institute, Miami, Florida 33101, USA.
Objective:
To describe a rare complication of intratympanic injection of steroids in susceptible ears.
Patients:
We present two patients with a history of irradiation involving the injected ear.
Intervention:
Therapeutic.
Main Outcome Measure:
Tympanic membrane condition after intratympanic injection of steroids.
Results:
Total or near-total breakdown of the irradiated tympanic membrane.
Conclusion:
Tympanic membranes with an impaired wound-healing ability, together with exposure to intratympanic steroids, may be at risk for total or near-total breakdown.

