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Updated: Jul 14, 2026
05:58
Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
Published on: February 3, 2021
Coronary circulation responses to binodenoson, a selective adenosine A2A receptor agonist
John McB Hodgson1, Nabil Dib, Morton J Kern
1St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. john.hodgson@chw.edu
The American Journal of Cardiology
|May 29, 2007
Summary
The 1.5 microg/kg binodenoson bolus dose effectively induces coronary hyperemia, comparable to adenosine, with a favorable safety profile in patients undergoing cardiac catheterization.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Coronary hyperemia is crucial for assessing myocardial blood flow.
- Adenosine is a standard agent for inducing hyperemia, but has limitations.
Purpose of the Study:
- To determine binodenoson dosing regimens for optimal coronary hyperemia.
- To evaluate binodenoson's safety and tolerability in patients.
Main Methods:
- Open-label, randomized, multicenter study with 133 adult patients.
- Coronary blood flow velocity (CBFV) measured via Doppler wire.
- Patients received varying doses of binodenoson via infusion or bolus injection.
Main Results:
- Binodenoson induced dose-dependent coronary hyperemia within seconds.
- 1.5 and 3 microg/kg doses produced maximal hyperemia equivalent to CBFV reserve.
- The 1.5 microg/kg bolus dose was sustained and associated with modest hemodynamic changes and no ECG abnormalities.
Conclusions:
- A 1.5 microg/kg binodenoson bolus dose achieves maximal coronary hyperemia.
- Binodenoson is well-tolerated and offers a promising alternative for hyperemia induction.
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