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Multiple sclerosis in Isfahan, Iran.

Mohammad Saadatnia1, Masoud Etemadifar, Amir Hadi Maghzi

  • 1Department of Neurology, Isfahan University of Medical Sciences, Isfahan 81744, Iran.

International Review of Neurobiology
|May 29, 2007
PubMed
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This study found a higher prevalence of multiple sclerosis (MS) in Isfahan, Iran, than previously reported, with a notable female predominance. The incidence rate may be increasing, suggesting Isfahan is a medium- to high-risk area for MS.

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with varying prevalence worldwide.
  • Understanding regional variations in MS prevalence and incidence is crucial for public health planning and resource allocation.
  • Iran, particularly the Isfahan region, has been identified as an area requiring further epidemiological investigation for MS.

Purpose of the Study:

  • To determine the prevalence and incidence of multiple sclerosis (MS) in Isfahan, Iran.
  • To describe the clinical and demographic characteristics of MS patients in Isfahan.
  • To compare these findings with existing global and regional MS data.

Main Methods:

  • A cross-sectional study was conducted in Isfahan, Iran, from 2003 to 2006.

Related Experiment Videos

  • Data were collected from 1718 diagnosed MS patients registered with the Isfahan MS Society (IMSS).
  • Prevalence, incidence, age of onset, disease duration, and clinical presentations were analyzed according to McDonald's criteria.

    • Main Results:

    • The overall period prevalence of MS was 43.8/100,000, with a female-to-male ratio of 3.4:1.
    • The incidence rate in 2005 was 3.64/100,000, indicating a potential increase.
    • Common initial symptoms included sensory (51.7%) and visual (47.5%) disturbances; specific subgroups like early-onset, late-onset, familial, and conjugal MS were identified.

    Conclusions:

    • Isfahan represents a medium- to high-risk area for MS, with prevalence rates exceeding previous estimates.
    • The observed increase in incidence may contribute to the higher prevalence.
    • Clinical and demographic features align with global trends, though some regional variations warrant further investigation.