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Contact allergy in oral disease
Rochelle R Torgerson1, Mark D P Davis, Alison J Bruce
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Journal of the American Academy of Dermatology
|May 29, 2007
Summary
Contact allergy to common oral substances like metals and preservatives is prevalent in patients with oral diseases. These allergies may significantly contribute to various oral conditions, impacting patient health.
Area of Science:
- Oral medicine
- Dermatology
- Allergology
Background:
- The connection between contact allergy and oral diseases remains largely uncharacterized.
- Investigating oral contact allergy is crucial for understanding and managing oral pathologies.
Purpose of the Study:
- To ascertain the prevalence of contact allergy to specific agents in individuals with oral conditions.
- To identify common allergens implicated in oral disease processes.
Main Methods:
- Retrospective analysis of 331 patients undergoing an 85-item oral antigen screening.
- Patch testing was employed to assess allergic reactions to flavorings, preservatives, dental acrylates, medications, and metals.
Main Results:
- 148 out of 331 patients (44.7%) exhibited positive patch test results.
- Nickel sulfate, gold sodium thiosulfate, and potassium dicyanoaurate were among the most frequent allergens.
- 221 of 341 positive reactions (64.8%) were deemed clinically relevant.
Conclusions:
- Contact allergy to metals, fragrances, and preservatives is linked to oral diseases.
- Positive allergic reactions suggest a potential role for contact allergy in the pathogenesis of oral conditions.
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