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Pulsatile gonadotropin output in menstrual dysfunction.

A C Wentz, G S Jones, K Sapp

    Obstetrics and Gynecology
    |March 1, 1976
    PubMed
    Summary
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    This study reveals distinct luteinizing hormone (LH) pulse patterns in various menstrual dysfunctions. Analyzing these patterns alongside responses to gonadotropin-releasing hormone (GnRH) can indicate the extent of hypothalamic dysfunction.

    Area of Science:

    • Reproductive Endocrinology
    • Neuroendocrinology

    Background:

    • Gonadotropin secretion is pulsatile, regulated by the hypothalamic-pituitary-ovarian axis.
    • Menstrual dysfunction can arise from disruptions in this axis.

    Purpose of the Study:

    • To characterize luteinizing hormone (LH) and follicle-stimulating hormone (FSH) pulsatile output in normal women and those with menstrual dysfunction.
    • To assess the relationship between LH pulsatility, response to gonadotropin-releasing hormone (GnRH), and the degree of hypothalamic dysfunction.

    Main Methods:

    • Radioimmunoassay measurement of LH and FSH every 20 minutes for 6-8 hours.
    • Administration of synthetic GnRH (also known as luteinizing hormone-releasing hormone, LRH) and subsequent monitoring of hormone output.

    Main Results:

    Related Experiment Videos

    • Normal follicular phase LH pulses occurred every 1-2 hours; luteal phase pulses were less frequent and higher amplitude.
    • Anorexia nervosa showed minimal LH activity and variable GnRH response.
    • Post-pill/postpartum amenorrhea and polycystic ovarian disease exhibited distinct LH pulsatility patterns.
    • LH pulsatility patterns varied significantly across different menstrual dysfunctions.

    Conclusions:

    • LH pulsatile activity patterns differ in various menstrual dysfunctions.
    • LH pulsatility and GnRH response may predict the degree of hypothalamic dysfunction.
    • Analysis of LH pulsatility in conjunction with GnRH stimulation offers insights into hypothalamic control mechanisms.