Lead discovery by DNA-encoded chemical libraries
Related Experiment Video
Updated: Jul 14, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Published on: May 16, 2021
Samu Melkko1, Christoph E Dumelin, Jörg Scheuermann
1Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland. samu.melkko@philochem.ch
Abstract:
The isolation of specific binding molecules is a central problem in the drug discovery process and might be useful for the elucidation of the biological function of proteins identified in genome and proteome research. Libraries of organic molecules, conjugated covalently to DNA tags that serve as identification bar codes, have been proposed recently as a way to identify ligands of target proteins of choice efficiently. Here, we analyze the different strategies for constructing DNA-encoded chemical libraries, and the potential and challenges of this promising technology.
More Related Videos
10:17Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
Published on: January 14, 2020
08:43A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules
Published on: March 10, 2017
Related Concept Videos
Drug Discovery: Overview
Labeling DNA Probes
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
DNA Microarrays
Maxam-Gilbert Sequencing
Challenges of the Maxam-Gilbert Method
The...