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Published on: January 13, 2023
Synthesis, antifungal and antimicrobial activity of alkylphospholipids
Daniel Obando1, Fred Widmer, Lesley C Wright
1School of Chemistry, The University of Sydney, NSW, Australia.
Abstract:
The antifungal, antibacterial and haemolytic activity of a series of alkylphosphocholines (e.g., miltefosine) and alkylglycerophosphocholines (e.g., edelfosine) has been investigated. These compound classes exhibit significant antifungal and moderate antibacterial activities. Several new alkylphosphocholine derivatives with amide or ester bonds in the alkyl chain have been synthesised. These compounds show much lower haemolytic activity than miltefosine. Alkylphosphocholines and alkylglycerophosphocholines show significant promise as novel orally available antifungal and antibacterial therapeutics.
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