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Updated: Apr 13, 2026

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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
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Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles
Farhad Ali Mohammed1,2, Hua Tong1, Chris S Hawes3
1Department of Chemistry, Maynooth University, National University of Ireland, Maynooth, Co, Kildare, Ireland. robert.elmes@mu.ie.
Abstract:
We report a new class of sequence-defined peptidomimetic macrocycles, termed squaratides, that incorporate squaramide units into a tunable peptide backbone. These modular receptors can bind acetate and chloride ions where sidechain functionality can control affinity and stoichiometry.

