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A self-powered biosensing platform for U937 cell detection and the induction of mitochondrial aggregation
Wenwen Xu1, Yalong Qiao1, Qiuting Wang1
1Anhui Key Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Molecular Sciences, Anhui Normal University, Wuhu, 241002, P. R. China. phling@ahnu.edu.cn.
Chemical Communications (Cambridge, England)
|September 23, 2026
Abstract:
An EBFC platform was developed for U937 cell detection via aptamer-triggered glucose oxidation. The generated electrons reduced cathode Fe3+, disrupting an alginate hydrogel to release mitochondrial-targeting nanoparticles. Intracellularly, ATP-induced DNA hybridization caused mitochondrial aggregation and ROS-mediated intervention, achieving closed-loop cancer diagnostics and intervention.