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Lymphadenopathy, elevated liver function tests and weight loss in a 68-year-old man
Karen L Krok1, Micheal S Torbenson, Richard D Schulick
1Division of Gastroenterology and Hepatology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Journal of Digestive Diseases
|May 30, 2007
Summary
This case report details a rare instance of Rosai-Dorfman disease, a non-malignant disorder, affecting the liver. The patient presented with classic symptoms, leading to a diagnosis confirmed by liver biopsy.
Area of Science:
- Hepatology
- Pathology
- Immunohistochemistry
Background:
- Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disorder characterized by lymphadenopathy and systemic symptoms.
- Hepatic involvement in RDD is uncommon, making diagnosis and management challenging.
Observation:
- A 68-year-old male presented with fever, weight loss, lymphadenopathy, and abnormal liver enzymes.
- Liver biopsy revealed characteristic histiocytes with emperipolesis (phagocytosis of lymphocytes) and positive S-100 immunostaining.
Findings:
- The patient was diagnosed with Rosai-Dorfman disease based on clinical presentation and histopathological findings.
- The diagnosis was confirmed through characteristic histiocytes and positive S-100 staining on liver biopsy.
Implications:
- This case highlights the importance of considering RDD in the differential diagnosis of unexplained liver dysfunction and systemic symptoms.
- Early diagnosis and appropriate management are crucial for patients with hepatic Rosai-Dorfman disease to prevent potential complications.
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