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Cardioprotective effect of spontaneous activity
S Peltier1, V Novel-Chate, W J Malaisse
1Unité de Formation et de Recherche en Activités Physiques et Sportives, Université Joseph Fourier, Grenoble, France. sepeltier@laposte.net
International Journal of Sports Medicine
|May 31, 2007
Summary
Lou/C rats naturally combine low caloric intake and exercise. Spontaneous wheel running in these rats improved cardiac recovery after ischemia-reperfusion injury, suggesting a protective effect against heart damage.
Area of Science:
- Cardiovascular Physiology
- Exercise Science
- Animal Models
Background:
- Understanding cardioprotective effects of combined low caloric intake and exercise is crucial.
- Lou/C rats spontaneously exhibit low caloric intake and exercise, making them a unique model.
- Limited data exists on the cardiac function of Lou/C rats.
Purpose of the Study:
- To document cardiac function in Lou/C rats before and after ischemia.
- To investigate if spontaneous wheel-running activity enhances cardiac recovery post-ischemia.
- To compare cardiac function between Wistar sedentary, Lou/C sedentary, and Lou/C wheel-running rats.
Main Methods:
- Isolated Langendorff hearts from Wistar sedentary, Lou/C sedentary, and Lou/C wheel-running rats were used.
- Hearts were subjected to 20-minute low-flow ischemia followed by 20-minute reperfusion.
- Cardiac mechanical function (rate-pressure product) and metabolic function (glycolysis flux) were measured.
Main Results:
- Lou/C sedentary rats showed reduced cardiac work before ischemia compared to Wistar sedentary rats.
- Wheel running in Lou/C rats decreased heart rate and oxygen consumption but increased coronary flow and non-oxidative glycolysis.
- Lou/C rats that underwent wheel running demonstrated improved recovery of cardiac mechanical function and efficiency after ischemia-reperfusion.
Conclusions:
- Ischemia-reperfusion injury impacts Lou/C and Wistar sedentary rats similarly.
- Spontaneous wheel-running activity in Lou/C rats reduces cardiac efficiency pre-ischemia.
- Wheel running confers protection against ischemia-reperfusion injury in isolated Lou/C rat hearts.
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