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Pathological crying induced by deep brain stimulation.

Lars Wojtecki1, Janpeter Nickel, Lars Timmermann

  • 1Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.

Movement Disorders : Official Journal of the Movement Disorder Society
|May 31, 2007
PubMed
Summary
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Pathological crying, a symptom in various diseases, may stem from disruptions in cortical-cerebellar pathways. Parkinson's disease patients stimulated in the subthalamic nucleus showed this, suggesting STN and ponto-cerebellar pathways modulate crying.

Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Pathological crying (PLC) is an emotional response incongruent with the eliciting stimulus, observed across diverse neurological and psychiatric conditions.
  • Current theories propose PLC arises from disruptions in higher-order cortical-cerebellar communication networks responsible for psychomotor response modulation.

Observation:

  • This study details a case of pathological crying (PLC) in a patient diagnosed with Parkinson's disease.
  • The PLC episodes were specifically observed during the stimulation of the subthalamic nucleus (STN), primarily on the right side of the brain.

Findings:

  • Positron emission tomography (PET) imaging revealed thalamo-ponto-cerebellar activation during STN stimulation in the patient experiencing PLC.
  • These neuroimaging results implicate the subthalamic nucleus (STN) and potentially ponto-cerebellar pathways in the neural circuitry underlying psychomotor control and the generation of pathological crying.

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Implications:

  • The findings suggest that the subthalamic nucleus (STN) plays a crucial role in the modulation of pathological crying (PLC).
  • This research highlights the involvement of ponto-cerebellar pathways in the complex mechanisms governing emotional expression and psychomotor regulation.
  • Understanding these pathways could lead to novel therapeutic targets for managing pathological crying in various neurological disorders.