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Related Experiment Video

Updated: Jul 14, 2026

A Dorsal Skinfold Window Chamber Tumor Mouse Model for Combined Intravital Microscopy and Magnetic Resonance Imaging in Translational Cancer Research
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Conductive interstitial thermal therapy (CITT) device evaluation in VX2 rabbit model.

Gal Shafirstein1, Leah Hennings, Yihong Kaufmann

  • 1Dept. of Otolaryngology, Univ. of Arkansas, Medical Sciences, 4301 West Markham, Little Rock, AR, USA. Shafirsteingal@uams.edu

Technology in Cancer Research & Treatment
|May 31, 2007
PubMed
Summary

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Conductive interstitial thermal therapy (CITT) precisely delivers thermal doses to surgical margins after tumor removal. This innovative CITT device effectively ablates cancerous tissue, preventing local tumor recurrence in early-stage cancers.

Area of Science:

  • Oncology
  • Medical Devices
  • Surgical Technology

Background:

  • Tumor resection can leave residual microscopic disease at surgical margins, increasing the risk of local recurrence.
  • Precise and reliable methods are needed to ensure complete eradication of tumor cells at the resection site.
  • Intraoperative thermal ablation offers a potential solution for achieving negative surgical margins.

Purpose of the Study:

  • To develop and evaluate a conductive interstitial thermal therapy (CITT) device for intraoperative thermal ablation.
  • To model and determine optimal parameters for CITT ablation of perfused tissues.
  • To assess the efficacy and safety of CITT in eradicating tumor cells at surgical margins.

Main Methods:

  • Finite element modeling (Femlab) was used to predict temperature fields during CITT ablation.

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  • VX2 carcinoma tumors in rabbits were ablated using the CITT device with optimized parameters (120°C, 20 minutes).
  • Viability staining (TTC) and histopathological examination (PCNA, cell morphology) were used to assess the ablated region and surrounding tissue.

    • Main Results:

    • Modeling indicated that 120°C for 20 minutes is required for ablating highly perfused VX2 carcinoma.
    • Histopathology revealed distinct zones: carbonized (1-3 mm), thermally fixed cells (PCNA+), and coagulated necrosis (5-10 mm).
    • Adjacent normal tissue was spared, demonstrating clear demarcation between ablated and viable tissue.

    Conclusions:

    • The conductive interstitial thermal therapy (CITT) device precisely delivers controlled thermal doses for intraoperative ablation.
    • CITT effectively ablates tumor tissue and creates a clear margin between treated and normal tissue.
    • CITT shows potential for clinical use in preventing local recurrence of non-metastatic, early-stage tumors by ensuring negative surgical margins.