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Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Related Experiment Video

Updated: Jul 14, 2026

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
07:56

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Use of asthmatic pulmonary function test data to predict lung deposition.

Risa J Robinson1, Richard L Doolittle, John N Diflorio

  • 1Department of Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, 76 Lomb Memorial Drive, Rochester, NY 14623, USA. rjreme@rit.edu

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|June 1, 2007
PubMed
Summary

Asthma significantly increases inhaled particle deposition by 54% due to altered breathing patterns and airway resistance. Realistic in vivo conditions are crucial for accurate asthma particle deposition studies.

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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

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Last Updated: Jul 14, 2026

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
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Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging

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Area of Science:

  • Pulmonary Medicine
  • Computational Biology
  • Environmental Health

Background:

  • Asthma alters breathing and airway structure, impacting inhaled particle deposition.
  • Limited data exists on particle deposition under realistic in vivo asthmatic conditions.
  • Accurate risk assessment for inhaled pathogens in asthmatics requires improved modeling.

Purpose of the Study:

  • To simulate particle deposition in asthmatic and healthy airways using realistic in vivo breathing conditions.
  • To quantify the difference in particle deposition between asthmatic and healthy individuals.
  • To evaluate the impact of altered lung function parameters on particle deposition.

Main Methods:

  • A 1D Eulerian modeling approach simulated particle deposition.
  • Asthmatic airway morphology was modeled by adjusting functional residual capacity (FRC) and airway resistance (Raw).
  • Data from 18 clinical studies informed lung volumes, resistance, and breathing conditions for healthy and asthmatic subjects.

Main Results:

  • Asthmatic subjects showed significantly higher Raw, FRC, and tidal volume (TV) compared to healthy subjects.
  • Simulations revealed a 54% average increase in particle deposition in asthmatic conditions versus healthy.
  • Particle deposition differences due to asthmatic conditions exceeded intersubject variability in healthy individuals.

Conclusions:

  • Realistic asthmatic breathing conditions significantly increase particle deposition compared to controlled experimental patterns.
  • Computational modeling with in vivo parameters provides critical insights into asthma-related particle deposition.
  • Caution is advised when interpreting experimental particle deposition data lacking realistic subject breathing patterns.