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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
[Optimization of preparation for matrine-loaded magnetic chitosan microspheres]
Xiao-ping Liu1, Ying Wang, Lie-xiang Yan
1College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
Objective:
To study the technique of preparation and optimization of magnetic chitosan microspheres.
Methods:
Magnetic fluid was produced by co-precipitation method and magnetic chitosan microspheres were produced using a convenient method of ionic gelation. A global optimization algorithm was used to optimize the parameters.
Results:
The formulated magenetic fluid and microspheres were characterized size and the size distribution. The average particle size of magnetic fluid and matrine-loaded chitosan magnetic microspheres were found to be 152.2 nm and 682.4 nm.
Conclusion:
Global optimization algorithm is an efficient method to optimize the parameters.
