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Updated: Jul 14, 2026
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Late-onset post-traumatic Phaeoacremonium parasiticum endophthalmitis
Tu Khai Huynh1, Lawrence R Lee, David Ellis
1The Royal Brisbane Hospital, Herston, Queensland, Australia. zztuhuy@fox.uq.net.au
Clinical & Experimental Ophthalmology
|June 2, 2007
Summary
This study documents the first case of Phaeoacremonium parasiticum causing endophthalmitis, an eye infection. Prompt treatment with antifungal medications successfully preserved the patient's vision, avoiding eye removal.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Phaeoacremonium parasiticum is a fungus known to cause infections in skin, joints, and endocarditis.
- Ocular infections by P. parasiticum have not been previously documented in medical literature.
Observation:
- A patient presented with endophthalmitis, a severe eye infection.
- A history of penetrating eye injury from a stick 5 years prior was noted as the likely inoculation source.
Findings:
- The patient was treated with intravitreal antibiotics, amphotericin, and oral voriconazole.
- Vision stabilized at 6/18, and enucleation (eye removal) was avoided.
- Microbiological studies confirmed the fungus's sensitivity to amphotericin B and voriconazole.
Implications:
- This case expands the spectrum of diseases caused by P. parasiticum to include endophthalmitis.
- Highlights the importance of considering P. parasiticum in cases of fungal endophthalmitis, especially after penetrating eye trauma.
- Demonstrates the efficacy of a combination antifungal treatment regimen in managing this rare ocular infection.
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