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Updated: Jul 14, 2026
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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Adjunctive fast repetitive transcranial magnetic stimulation in depression
Ian M Anderson1, Nicola A Delvai, Bettadapura Ashim
1Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK. ian.anderson@manchester.ac.uk
Summary
Fast, left frontal repetitive transcranial magnetic stimulation (rTMS) showed efficacy in treating depression, including treatment-resistant cases. This rTMS therapy was well-tolerated and demonstrated sustained improvement over 12 weeks.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Medicine
Background:
- The therapeutic role of repetitive transcranial magnetic stimulation (rTMS) for depression is not fully established.
- Treatment-resistant depression poses a significant clinical challenge.
Purpose of the Study:
- To evaluate the efficacy and acceptability of fast, left frontal rTMS in patients with depression.
- To assess the durability of treatment response up to 12 weeks.
Main Methods:
- A sham-controlled study involving 29 patients with depression (79% treatment-resistant).
- Administered fast, left frontal rTMS three times per week for 4-6 weeks.
- Compared active rTMS to sham treatment.
Main Results:
- The procedure was generally well-tolerated.
- Active rTMS was significantly more effective than sham treatment (55% vs. 77% responding, P<0.05).
- Treatment benefits were maintained at 12 weeks.
Conclusions:
- Fast, left frontal rTMS appears to be a safe and effective treatment option for depression.
- This rTMS therapy could be a valuable addition to existing depression treatments.
- Further research is required to optimize treatment parameters for rTMS in depression.
