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[Peripheral anticholinergic syndrome]
Martha Patricia Valencia Zavala1, Gloria Bertha Vega Robledo, Jesús Alberto Sánchez Olivas
1Médica adscrita al servicio de alergia e inmunología clínica, Hospital General de México. mipsins@hotmail.com
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|June 5, 2007
Summary
Oral antihistamines, used for allergic rhinitis, can cause peripheral anticholinergic syndrome (PAS). This syndrome may lead to functional urinary obstruction and bladder sphincter issues, as seen in a case report.
Area of Science:
- Allergy and Immunology
- Urology
Background:
- A 38-year-old woman presented with allergic rhinitis, diagnosed via clinical evaluation and laboratory tests.
- Treatment initiated included specific hyposensitization, oral antihistamines, and inhaled corticosteroids.
Observation:
- Two years post-treatment, the patient developed urinary retention without prior history.
- Peripheral anticholinergic syndrome (PAS) was suspected as the cause.
Findings:
- Urodynamic studies, including uroflometry, urethral pressure profiling, cystometry, and electromyography, were performed.
- The studies revealed functional low urinary obstruction and vesical sphincter pseudodysfunction.
Implications:
- This case report demonstrates a link between oral antihistamine use and the development of peripheral anticholinergic syndrome (PAS).
- PAS can manifest as functional urinary obstruction and bladder sphincter dysfunction, highlighting a potential adverse effect of common allergy medications.
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