[Early diagnosis and prognosis of bacterial tubulo-interstitial nephritis in children]

The authors provide the data of a prospective follow-up of children with diseases of the urinary system organs. Analysis was made of the role of endogenous and exogenous factors in the formation of abacterial and bacterial tubulointerstitial nephritis (TIN) in children with predisposing conditions. It has been established that progression of the tubulointerstitial process can be seen in patients infected with causative agents capable of intracellular parasitizing and persistence in the body. Depending on the intensity of membranopathological and immune disorders the clinicopathogenetic manifestations of different stages of TIN are described in detail. It is shown that there is a possibility of early diagnosis of the bacterial stage of the disease on the basis of detecting the persistent microflora according to an assay of the antilysozyme activity of the causative agent and the urine content of beta-lysines in urine. The authors base the necessity of the preventive treatment of children with predisposing conditions and abacterial TIN to avert the formation and progression of bacterial TIN by means of agents that may prevent the persistence of causative agents and raising the efficacy of antiinfectious defence of the macroorganism.