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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Autonomic nervous system dysfunction after spinal cord injury.

Susan V Garstang1, Stacey A Miller-Smith

  • 1Department of Physical Medicine and Rehabilitation, UMNDJ-New Jersey Medical School, 30 Bergen Street, ADMC 101, Newark, NJ 07039, USA. garstasv@umdnj.edu

Physical Medicine and Rehabilitation Clinics of North America
|June 5, 2007
PubMed
Summary

Autonomic nervous system (ANS) dysfunction is critical after spinal cord injury, as it directly causes many physiological changes. Understanding ANS dysregulation is key for managing altered physiology in these patients.

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Area of Science:

  • Neuroscience
  • Physiology

Background:

  • The autonomic nervous system (ANS) regulates vital physiologic processes through central nervous system control.
  • Autonomic dysfunction is a significant concern in individuals with spinal cord injuries (SCIs).

Purpose of the Study:

  • To highlight the crucial role of the autonomic nervous system (ANS) in the pathophysiology of spinal cord injuries.
  • To emphasize the importance of understanding ANS dysregulation for managing altered physiology post-SCI.

Main Methods:

  • This abstract is based on a review of existing literature on autonomic nervous system function and spinal cord injury.
  • Analysis of physiological changes associated with autonomic dysregulation in SCI populations.

Main Results:

  • Supraspinal centers modulate ANS functions.
  • Altered physiology in SCI patients is frequently a direct result of ANS dysregulation.

Conclusions:

  • Understanding autonomic nervous system (ANS) dysfunction is essential for comprehending and managing the complex physiological alterations following spinal cord injury.
  • Further research into ANS regulation post-SCI can improve patient outcomes.