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Updated: Jul 14, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
Early pediatric anthracycline cardiotoxicity: managed by serial heart and bone marrow transplantation
Jasveer S Mangat1, Kanchan Rao, Judith Kingston
1Department of Paediatric Cardiology, Great Ormond Street Hospital, London, UK. jasveer_mangat@yahoo.com
Abstract:
We report a favorable outcome in a child who underwent cardiac transplantation for severe early post-anthracycline-induced cardiomyopathy, 9 months after completion of treatment for acute myeloid leukemia (AML). The child suffered a relapse of AML 2 months after cardiac transplantation and then underwent a successful bone marrow transplant. This case is unique in the literature. We believe it offers an alternative strategy for children with hematologic malignancies, where severe early post-anthracycline cardiotoxicity might preclude bone marrow transplantation.
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