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A trace display and editing program for data from fluorescence based sequencing machines.

T Gleeson1, L Hillier

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.

Nucleic Acids Research
|December 11, 1991
PubMed
Summary
This summary is machine-generated.

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Ted (Trace editor) is a graphical tool that enhances the efficiency and accuracy of DNA sequence editing. This software aids in processing trace data from automated sequencers, proving valuable for large-scale genome projects.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Automated fluorescence sequencing generates large volumes of sequence and trace data.
  • Accurate editing of this data is crucial for reliable genome assembly and analysis.
  • Existing tools may lack comprehensive features for efficient trace data manipulation.

Purpose of the Study:

  • To introduce Ted (Trace editor), a graphical software for editing DNA sequence and trace data.
  • To describe the functionalities of Ted that facilitate efficient and accurate sequence editing.
  • To highlight the utility of Ted in large-scale sequencing projects like C.elegans.

Main Methods:

  • Development of a graphical user interface for sequence and trace data visualization.
  • Implementation of automated and manual trimming features for sequence data.

Related Experiment Videos

  • Integration of trace scaling and editing history functionalities.

    • Main Results:

    • Ted provides comprehensive tools for viewing, editing, and trimming sequence and trace data.
    • The software supports data from ABI 373A and Pharmacia A.L.F. sequencers.
    • Extensive use in the C.elegans genome project demonstrated improved editing efficiency and accuracy.

    Conclusions:

    • Ted significantly enhances the process of DNA sequence and trace data editing.
    • Its features contribute to greater accuracy and efficiency in genomic research.
    • Ted is a valuable tool for researchers working with automated sequencing data.