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An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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Photodynamic therapy with lasers and intense pulsed light.
1Gold Skin Care Center, Tennessee Clinical Research Center, 2000 Richard Jones Road, Suite 220, Nashville, TN 37215, USA. goldskin@goldskincare.com
Facial Plastic Surgery Clinics of North America
|June 5, 2007
Summary
Aminolevulinic acid photodynamic therapy (ALA-PDT) is effective for photorejuvenation, offering cosmetic benefits beyond treating actinic keratoses. This review covers ALA-PDT literature and clinical techniques for skin rejuvenation.
Area of Science:
- Dermatology
- Photomedicine
- Cosmetic Procedures
Background:
- Photodynamic therapy (PDT) is increasingly used with lasers and light sources in photorejuvenation.
- Aminolevulinic acid photodynamic therapy (ALA-PDT) was initially developed for actinic keratoses treatment.
- Cosmetic benefits of ALA-PDT for actinic keratoses were observed, prompting further investigation.
Purpose of the Study:
- To review the peer-reviewed literature on ALA-PDT for photorejuvenation.
- To summarize clinical techniques for utilizing ALA-PDT in cosmetic skin treatments.
- To evaluate the efficacy of ALA-PDT in improving photorejuvenation outcomes.
Main Methods:
- Literature review of studies on ALA-PDT in photorejuvenation.
- Analysis of clinical trial data confirming ALA-PDT effectiveness.
- Summary of author's practical techniques and experiences with ALA-PDT.
Main Results:
- Clinical trials confirm ALA-PDT's effectiveness in photorejuvenation.
- ALA-PDT provides significant cosmetic benefits, with or without actinic keratoses.
- The therapy is a valuable tool for physicians seeking improved photorejuvenation outcomes.
Conclusions:
- ALA-PDT is an established and effective therapy for photorejuvenation.
- The dual action of treating skin conditions and enhancing cosmetic appearance makes ALA-PDT highly beneficial.
- Physicians can confidently integrate ALA-PDT into their photorejuvenation protocols.

