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Cutaneous polyarteritis nodosa
José L Díaz-Pérez1, Zuriñe Martínez De Lagrán, José Luis Díaz-Ramón
1Department of Dermatology, Hospital de Cruces, Baracaldo, Vizcaya, Spain. jldiaz@hcru.osakidetza.net
Seminars in Cutaneous Medicine and Surgery
|June 5, 2007
Summary
Cutaneous polyarteritis nodosa (PAN) presents as nodules on the legs, often with ulceration and pain. Treatment includes salicylates, corticosteroids, and penicillin for elevated ASO titers.
Area of Science:
- Dermatology
- Rheumatology
- Pathology
Background:
- Polyarteritis nodosa (PAN) encompasses systemic, cutaneous, and microscopic forms.
- Cutaneous PAN specifically affects the deep dermis and panniculus, characterized by arteritis.
Purpose of the Study:
- To describe the clinical and histopathological features of cutaneous PAN.
- To outline the diagnostic criteria and treatment approaches for cutaneous PAN.
Main Methods:
- Review of clinical manifestations and anatomopathological findings in cutaneous PAN.
- Histopathological analysis of skin nodules revealing necrotizing arteritis and panniculitis.
Main Results:
- Cutaneous PAN commonly presents with nodules on lower legs, varying in development and potentially causing persistent skin changes or ulceration.
- Associated symptoms include pain, arthralgias, malaise, and fever.
- Histopathology confirms necrotizing arteritis of deep dermal or pannicular arteries with focal panniculitis.
Conclusions:
- Cutaneous PAN is a distinct vasculitis with characteristic clinical and histopathological features.
- Management involves symptomatic relief with salicylates, anti-inflammatory effects from corticosteroids, and antibiotics for specific cases.
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