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Updated: Jul 14, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Necrobiosis lipoidica
Jordi Peyrí1, Abelardo Moreno, Joaquin Marcoval
1Department of Dermatology, Hospital Universitari de Bellvitge, Barcelona, Spain. jpeyri@csub.scs.es
Abstract:
Necrobiosis lipoidica (NL) is a granulomatous condition with a degenerative connective tissue of unknown etiology very often associated with diabetes. Histopathologically, NL involves all of the dermis and, often, the subcutaneous fat produces a septal panniculitis. There are some changes suggesting the diagnosis of NL, and systemic disease should be considered if there is the presence of necrotizing vasculitis in the skin biopsy. Many theories of pathogenesis have been proposed, and many types of drugs are available for use in its treatment.
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