Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contemporary concepts in noncellular rejection.

Jon A Kobashigawa1

  • 1The David Geffen School of Medicine at UCLA, University of California at Los Angeles Medical Center, Los Angeles, CA 90095, USA. jonk@mednet.ucla.edu

Heart Failure Clinics
|June 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond Inoperable: Combined Heart-Liver Transplantation Rescues a Patient With Destructive Endocarditis and End-Stage Liver Disease.

The Annals of thoracic surgery·2026
Same author

Utilization and Outcomes of Permanent Pacemakers After Bicaval Heart Transplantation: A Large Institutional Experience.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Due to Increased Immune Therapies, Are Sensitized Heart Transplant Recipients at Increased Risk for Malignancies?

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Left Ventricular Apical Thrombus in a Post-Heart Transplant Patient With Preserved Ejection Fraction.

JACC. Case reports·2026
Same author

Impact and outcomes after desensitization therapy in highly sensitized heart transplant candidates.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025
Same author

The efficacy of biodegradable polymer everolimus-eluting stents in patients with cardiac allograft vasculopathy.

JHLT open·2025
Same journal

Pulmonary Vascular Disease Across the Continuum: From Mechanisms to Precision Care.

Heart failure clinics·2026
Same journal

Long-term Complications of Pulmonary Embolism: Which Is the Optimal Follow-Up?

Heart failure clinics·2026
Same journal

Recent Advances in Pulmonary Hypertension Management.

Heart failure clinics·2026
Same journal

The Role of Machine Learning and Artificial Intelligence in Drug Discovery and Clinical Care of Pulmonary Hypertension.

Heart failure clinics·2026
Same journal

Portopulmonary Hypertension: Current Perspectives.

Heart failure clinics·2026
Same journal

Exercise Training and Cardiac Rehabilitation in Chronic Thromboembolic Pulmonary Hypertension.

Heart failure clinics·2026
See all related articles

Antibody-mediated rejection is an increasing concern after heart transplants, leading to graft loss and mortality. Understanding noncellular rejection mechanisms is crucial for developing better treatments to improve patient outcomes.

Area of Science:

  • Cardiology
  • Immunology
  • Transplantation

Background:

  • Acute rejection significantly impacts morbidity and mortality within the first year post-cardiac transplantation.
  • While cellular rejection is common, noncellular rejection, often antibody-mediated, is increasingly recognized.

Purpose of the Study:

  • To highlight the growing importance of noncellular, antibody-mediated rejection in cardiac allografts.
  • To describe the clinical associations and histological findings of antibody-mediated rejection.
  • To outline current therapeutic strategies for severe noncellular rejection.

Main Methods:

  • Review of clinical data and histological findings from endomyocardial biopsies.
  • Immunofluorescence and immunoperoxidase studies to identify immunoglobulin and complement deposition.

Related Experiment Videos

  • Analysis of treatment regimens for patients with severe noncellular rejection.

    • Main Results:

    • Noncellular rejection, primarily antibody-mediated, is linked to hemodynamic compromise, graft loss, cardiac allograft vasculopathy, and increased mortality.
    • Histological examination often shows intravascular macrophages and immune complex deposition without lymphoid infiltrates.
    • Intense multi-agent therapy is required for severely affected patients.

    Conclusions:

    • Antibody-mediated rejection presents a significant threat to cardiac allograft survival and patient mortality.
    • Further research into noncellular rejection mechanisms is essential for advancing therapeutic interventions.
    • Improved understanding will facilitate the development of more targeted and effective treatments for antibody-mediated rejection.