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Memantine for behavioral disturbances in frontotemporal dementia: a case series
1Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307, USA. Margaret.Swanberg@us.army.mil
Background:
Frontotemporal dementia (FTD) is one of the more common presenile dementias. Unlike Alzheimer disease, there are no approved medications to treat this debilitating condition.
Objective:
To report the response of memantine on the behavioral manifestations of FTD.
Design:
Case series of 3 patients diagnosed with FTD and treated with memantine.
Results:
All 3 patients showed an improvement in total Neuropsychiatric Inventory score with specific improvements in the subscale scores of apathy, agitation, and anxiety. Memantine was well tolerated in all patients.
Conclusions:
This small case series supports the notion that memantine may have a beneficial effect on the neuropsychiatric symptoms of FTD and should be further studied in a prospective clinical trial.
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