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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Advanced therapeutic and prophylactic strategies for Epstein-Barr virus infection in immunocompromised patients
Motohiko Okano1, Thomas G Gross
1Department of Microbiology, Center for Infectious Diseases Control, Hokkaido Institute of Public Health, Kita-ku, Sapporo, Japan. okano_m@iph.pref.hokkaido.jp
Abstract:
Epstein-Barr virus (EBV) is an ubiquitous human herpesvirus. Primary infection is generally subclinical but in certain circumstances, such as in patients with either hereditary or secondary immunodeficiency, EBV infection may cause overt disease that is often lethal. Strategies for the prophylaxis and treatment of these potentially life-threatening complications of EBV infection have advanced dramatically. They include immunological-based approaches targeted at EBV-infected cells, as well as improvement in the treatment of the underlying and predisposing disease. This review will discuss EBV biology and immune events that occur in both immunocompetent and immunocompromised individuals and introduce the novel prophylactic and therapeutic strategies for EBV-associated life-threatening diseases.
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