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Updated: Jul 14, 2026
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CRISPR-Mediated Reorganization of Chromatin Loop Structure
Published on: September 14, 2018
[BTEB/KLF9 and its transcriptional regulation]
1Department of Pathology &Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310058, China. lingkang1220@yahoo.com.cn
Yi Chuan = Hereditas
|June 6, 2007
Summary
Basic transcription element-binding protein/Krüppel-like transcription factor 9 (BTEB/KLF9) is a zinc finger protein regulating gene transcription. It interacts with other factors, influencing cell processes like proliferation and differentiation.
Area of Science:
- Molecular Biology
- Gene Regulation
Background:
- Basic transcription element-binding protein/Krüppel-like transcription factor 9 (BTEB/KLF9) is a zinc finger protein.
- It belongs to the Krüppel-like transcription factor family, crucial for eukaryotic gene regulation.
Purpose of the Study:
- To elucidate the role and mechanism of BTEB/KLF9 in gene transcription.
- To understand its interactions and functions in cellular processes.
Main Methods:
- Analysis of BTEB/KLF9 mRNA and protein expression levels.
- Investigation of its DNA-binding properties via zinc finger motifs.
- Exploration of its interactions with other transcription factors and co-regulators.
Main Results:
- BTEB/KLF9 mRNA shows widespread expression, but protein levels are inconsistent.
- The protein binds to GC or GT/CACC boxes in gene regulatory regions.
- BTEB/KLF9 participates in regulating the reproductive system, cell proliferation, differentiation, and cell cycle.
Conclusions:
- BTEB/KLF9 acts as a transcription factor through specific DNA binding and interactions.
- It plays a significant role in various cellular functions and organismal development.
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