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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Sex Linked Disorders

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Confounding in Epidemiological Studies

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Related Experiment Video

Updated: Jul 14, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Conjugal multiple sclerosis in Isfahan, Iran: a population-based study.

A H Maghzi1, M Etemadifar, V Shaygannejad

  • 1Medical School, Isfahan University of Medical Sciences, Isfahan, 81744-176, Iran. maghzi@edc.mui.ac.ir

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 6, 2007
PubMed
Summary

Conjugal multiple sclerosis (MS) affects both spouses, with a 0.5% rate observed in this study. This rate is significantly higher than the general population risk, suggesting shared environmental factors may play a role in MS development.

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Last Updated: Jul 14, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Conjugal multiple sclerosis (MS) is a rare condition where both partners in a marriage are diagnosed with MS.
  • Understanding the risk factors for MS in spouses of affected individuals is crucial for public health.

Purpose of the Study:

  • To determine the rate of conjugal MS within a cohort of MS patients.
  • To assess the risk of MS in spouses of MS patients compared to the general population.

Main Methods:

  • Retrospective analysis of 1606 definite MS patients.
  • Identification of patients in marital relationships and their spouses.
  • Calculation of the conjugal MS rate and comparison with general population MS risk.

Main Results:

  • Six conjugal MS pairs were identified among 1076 married MS patients.
  • The observed conjugal MS rate was 0.5%.
  • This rate is 12.5 times higher than the estimated MS risk in the general population (0.04%).

Conclusions:

  • Spouses of MS patients have a significantly elevated risk of developing MS.
  • The increased risk may be attributed to shared environmental factors or, less likely, transmission.
  • Further research is warranted to elucidate the specific environmental triggers and potential transmission pathways.