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Could proteolytic enzyme modulate the interaction platelets/vessel wall in presence of ASA at ultra low doses?
M C Lalanne1, O de Seze, C Doutremepuich
1CJF Inserm 88/13, Laboratoire d'Hématologie, Bordeaux, France.
Thrombosis Research
|August 15, 1991
Abstract:
Acetylsalicylic acid (ASA) is known to act on platelets and vessel walls. At ultra low doses it reverses the inhibitory effects produced by a vascular fragment. Use of papain on normal platelets in vitro led to the appearance of platelet aggregation without collagen induction with a range of 20.25 +/- 28.91%. In the presence of vascular fragments (without ASA), this "spontaneous" aggregation remained but was reduced (13.26 +/- 27.73%). This effect was reversed by ASA treatment (29.41 +/- 24.17%). Reversion of vascular inhibition by ASA was not modified by papain.