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[Postinfectious glomerulonephritis in children in Lithuania during 1995-2004: prevalence and clinical features]

Augustina Jankauskiene1, Birute Pundziene, Renata Vitkevic

  • 1Vilnius University Children's Hospital, Vilnius, Lithuania. augustinajankauskiene@yahoo.com

Medicina (Kaunas, Lithuania)
|December 6, 2007
PubMed

Insights

Acute postinfectious glomerulonephritis (APIGN) incidence in children decreased significantly from 1995 to 2004. APIGN was commonly linked to infections, with edema and hypertension being frequent symptoms.

Area of Science:

  • Pediatrics
  • Nephrology
  • Epidemiology

Background:

  • Acute postinfectious glomerulonephritis (APIGN) is a significant renal disease in children.
  • Understanding its epidemiological trends and clinical manifestations is crucial for timely diagnosis and management.

Purpose of the Study:

  • To analyze the incidence, causes, clinical features, and outcomes of acute postinfectious glomerulonephritis in children over a 10-year period.
  • To identify trends in APIGN prevalence and associated risk factors.

Main Methods:

  • Retrospective analysis of 322 children diagnosed with APIGN between 1995 and 2004.
  • Data collection included patient demographics, preceding infections, clinical presentation, laboratory findings, and treatment outcomes.

Main Results:

  • APIGN incidence decreased from 8.3 to 2.2-2.4 cases per 100,000 children.
  • Most common preceding infections were upper respiratory tract (28.3%), tonsillitis (24%), and skin infections (24%).
  • Edema (70.3%), hypertension (55.5%), and transient renal failure (32.9%) were common; no deaths occurred.

Conclusions:

  • A notable decline in APIGN prevalence was observed.
  • Early recognition of infections preceding APIGN is important for prompt intervention.
  • The disease typically presents with edema and hypertension, with a generally favorable prognosis in children.

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