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Prostatic tissue levels of ofloxacin
J Aagaard1, J Knes, P O Madsen
1Urology Section, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
Abstract:
The prostatic tissue levels of ofloxacin were determined in 20 patients undergoing transurethral resection of the prostate. Ofloxacin was administered in two separate dosages of 300 mg PO from twenty-two to two hours preoperatively. The ofloxacin plasma concentrations ranged from 3.73 to 1.85 micrograms/mL at the time of surgery, and the tissue concentrations ranged from 4.55 to 1.94 micrograms/mL. The ofloxacin tissue/plasma ratios ranged from 0.9 to 1.2. These findings indicate that ofloxacin may be useful in prophylaxis prior to transurethral prostatic surgery and also in the treatment of bacterial prostatitis.
Insights
Ofloxacin demonstrates effective prostatic tissue concentrations, suggesting its utility for preventing infection before prostate surgery and treating bacterial prostatitis. This study evaluated ofloxacin levels in patients undergoing transurethral resection of the prostate.
Area of Science:
- Pharmacology
- Urology
- Infectious Diseases
Background:
- Bacterial prostatitis and surgical site infections are significant concerns in urological procedures.
- Antibiotic prophylaxis is crucial for transurethral prostatic surgery to minimize postoperative complications.
- Understanding antibiotic tissue penetration is vital for optimizing treatment efficacy.
Purpose of the Study:
- To determine the prostatic tissue and plasma concentrations of ofloxacin.
- To evaluate the efficacy of ofloxacin for prophylaxis and treatment in patients undergoing transurethral resection of the prostate (TURP).
Main Methods:
- Twenty patients undergoing TURP received ofloxacin 300 mg orally at two different preoperative time points.
- Prostatic tissue and plasma concentrations of ofloxacin were measured at the time of surgery.
Main Results:
- Ofloxacin plasma concentrations ranged from 1.85 to 3.73 µg/mL.
- Prostatic tissue concentrations ranged from 1.94 to 4.55 µg/mL.
- Tissue-to-plasma concentration ratios varied between 0.9 and 1.2.
Conclusions:
- Ofloxacin achieves significant prostatic tissue levels following oral administration.
- These findings support the use of ofloxacin for surgical prophylaxis in TURP patients.
- Ofloxacin may also be a viable therapeutic option for bacterial prostatitis.